Simulating Manufacturing Scale Aerobic Fermentation in Pressurized Miniature Bioreactors

Lead organization: Checkerspot, Inc. 

Project partners: University of California, Davis

Year launched: 2021 

This project will evaluate a pressurized scale-down model for fermentation development, to determine whether it can replace more costly intermediate scale fermentation systems. The system will be validated on multiple key performance indicators generated in both high- and low-cell density processes. Developing a novel capability to predict strain performance with high probability, in concordance with and validated by our other, more traditional platform technologies, is the ultimate goal of this work. This new predictive tool may help BioMADE members save significant time and investment capital for fermentation process scale-up. 

Funding source: BioMADE Project Call 1.0