Project Resources

BioMADE works to advance the domestic bioindustrial manufacturing industry. Sharing resources developed through BioMADE-funded projects is an important way all members can benefit from this groundbreaking research. Below, find resources from Technology and Innovation projects like instructions for simulating manufacturing-scale aerobic fermentation, best practices for using wireless sensors, and process instructions to improve and scale downstream processing. Resources from our Education and Workforce Development projects include curricula, instructions to build a DIY bioreactor, course materials, trainings, and much more. Also, find advice and insights related to bioindustrial manufacturing infrastructure.  

This content is available to BioMADE members only through the Member Portal.

Photo above © Tigermoth Photo

Technology and Innovation Resources

Education and Workforce Development Resources

Bioindustrial Manufacturing Infrastructure

  • Developing a first-of-a-kind facility is a significant milestone – and a challenging process – for many innovative bioindustrial manufacturing companies. From design and engineering to regulatory approval to community engagement, there are a wide range of issues that companies must navigate in order to be successful. BioMADE is excited to share a new resource for companies embarking upon first-of-a-kind facility projects: a collection of case studies featuring six members’ insights and lessons learned. Hear from:  

    • Amyris on scaling up their process, consulting with experts, and leveraging technoeconomic analysis  

    • Black & Veatch on how engineering, procurement, and construction firms can support small companies  

    • Mango Materials on how they partnered with feedstock providers and local government  

    • Manus on rebuilding a manufacturing community by forging relationships with employees and the future workforce   

    • Solugen on their approach to managing cost and schedule from design and engineering through construction  

    • Superbrewed Food on building for strategic flexibility, navigating regulatory pathways, and forging manufacturing partnerships 

    Access the first-of-a-kind facility case studies here. 

    • Post-Run Review of Squalene Scale-up
      Review this technology transfer report from Amyris that captures key lessons learned while supporting the successful scale-up of sustainable Squalene at a CDMO. These insights will help pave the way for smoother, more efficient tech transfers across the biomanufacturing community.

Member Webinars

  • Hear from fellow BioMADE members about their capabilities, services, and technologies to help you find partners that will advance your work. Catch up with:

    • AVN about supporting bio-based chemical process technology development

    • The University of Wisconsin-Madison Center for Dairy Research about turning dairy waste streams into valuable products

    • The University of California, Davis about their biomanufacturing capabilities and BioMADE project findings

    • AVEKA about scale-up development and saving costs in downstream processing

    • Citrine Informatics about how their platform's uncertainty-driven AI provides the crucial insights needed to dramatically accelerate development, minimizing wasted experiments and maximizing results

    • MIT Lincoln Lab about their capabilities, resources, current programs, emerging areas of interest, and collaboration opportunities.

    • Purdue University on how they can support your company and lab with continuing education and joint research programs and how you can develop new research and education partnerships

    • Battelle on how testing and evaluation is a critical component of successful bioproduct transition

    • Hear from the National Counterintelligence and Security Center about their work with partners across the U.S. Government and the private sector to provide expertise and guidance on a range of topics related to counterintelligence and security, including insider threats, investment security, cyber threats, supply chain risks, and foreign threats.

    • Hear from the Cybersecurity and Infrastructure Security Agency about the latest cyber threat landscape and an overview of CISA's key resources. This briefing will provide actionable insights to enhance your organization's cybersecurity posture and highlight tools and services available to support your resilience efforts.

Publications

    • Astolfi, M. C. T., Yoder, S. D., Delfa-Lalaguna, M., Winegar, P. H., Holm, S. K. F., Lei, M., Zhao, X., Tan, S. E., Louie, R., Hillson, N. J., Hudson, G. A., & Keasling, J. D. (2025). Automated strain construction for biosynthetic pathway screening in yeast. ACS Synthetic Biology, 14(10), 4143–4151. https://doi.org/10.1021/acssynbio.5c00554

    • Chen, X. (2023). Enabling chemoenzymatic strategies and enzymes for synthesizing Sialyl glycans and Sialyl glycoconjugates. Accounts of Chemical Research, 57(2), 234–246. https://doi.org/10.1021/acs.accounts.3c00614

    • Crowe, S. A., Liu, Y., Zhao, X., Scheller, H. V., & Keasling, J. D. (2024). Advances in engineering nucleotide sugar metabolism for natural product glycosylation in saccharomyces cerevisiae. ACS Synthetic Biology, 13(6), 1589–1599. https://doi.org/10.1021/acssynbio.3c00737

    • Crowe, S. A., Zhao, X., Gan, F., Chen, X., Hudson, G. A., Astolfi, M. C., Scheller, H. V., Liu, Y., & Keasling, J. D. (2024). Engineered Saccharomyces cerevisiae as a Biosynthetic Platform of Nucleotide Sugars. ACS Synthetic Biology, 13(4), 1215–1224. https://doi.org/10.1021/acssynbio.3c00666

    • Han, Z., Guo, A. X., Luo, T., Cai, T., & Mirkin, C. A. (2025). Biomineralization of semiconductor quantum dots using DNA-functionalized protein nanoreactors. Science Advances, 11(19). https://doi.org/10.1126/sciadv.adv6906

    • Huang, J., Wang, Z., Liang, J., Li, X.-Y., Pietryga, J., Ye, Z., Smith, P. T., Kulaksizoglu, A., McCormick, C. R., Kim, J., Peng, B., Liu, Z., Xie, K., Torrisi, S. B., Montoya, J. H., Wu, G., Sargent, E. H., & Mirkin, C. A. (2025). Accelerating the pace of oxygen evolution reaction catalyst discovery through Megalibraries. Journal of the American Chemical Society, 147(34), 30956–30966. https://doi.org/10.1021/jacs.5c08326

    • Kim, N., Lee, J., & Su, X. (2023). Precision tuning of highly selective polyelectrolyte membranes for redox‐mediated electrochemical separation of organic acids. Advanced Functional Materials, 33(12). https://doi.org/10.1002/adfm.202211645

    • Kuo, M.-T., & Reuel, N. F. (2025). Resolving the kinetics of single-walled carbon nanotube–polyester polyurethane nanoparticle conjugate fluorescence sensors toward polymer degrading enzymes. Nano Letters, 25(2), 715–721. https://doi.org/10.1021/acs.nanolett.4c04964

    • Liu, Y., Zhao, X., Gan, F., Chen, X., Deng, K., Crowe, S. A., Hudson, G. A., Belcher, M. S., Schmidt, M., Astolfi, M. C., Kosina, S. M., Pang, B., Shao, M., Yin, J., Sirirungruang, S., Iavarone, A. T., Reed, J., Martin, L. B., El-Demerdash, A., … Keasling, J. D. (2024). Complete biosynthesis of QS-21 in engineered yeast. Nature, 629(8013), 937–944. https://doi.org/10.1038/s41586-024-07345-9

    • Meyersohn, M. S., Block, A., Bates, F. S., & Hillmyer, M. A. (2024). Tackling the thermodynamic stability of low-ceiling temperature polymers for the preparation of tough and chemically recyclable thermoplastic polyurethane-urea elastomers. Macromolecules, 57(19), 9230–9240. https://doi.org/10.1021/acs.macromol.4c01431

    • Ophir, Y., Wong, J. H., Haddad, K. R., Huuskonen, A., Karmaker, A., Gore, V., Jung, S., Oloumi, A., Liu, Y., Fu, J., Zhang, L., Huang, P., Minami, S. A., Garimella, S. S., Thyagatur, A., Zaini, P. A., Vitikainen, M., Tchelet, R., Valbuena, N., ... Nandi, S. (2025). Expression and characterization of SARS-CoV-2 spike protein in Thermothelomyces heterothallica C1. Vaccine, 65, Article 127784. https://doi.org/10.1016/j.vaccine.2025.127784

    • Quezada, A., Annapareddy, A., Javanmardi, K., Cooper, J., & Finkelstein, I. J. (2024). Mammalian antigen display for pandemic countermeasures. Methods in Molecular Biology, 191–216. https://doi.org/10.1007/978-1-0716-3666-4_12

    • Shin, Donghoon, et al. “A-cation-dependent structure–optical property relationships of halide perovskite heterostructures with complex interfaces.” Journal of the American Chemical Society, 9 Oct. 2025, https://doi.org/10.1021/jacs.5c10848

    • Thomas, J., Bouscher, R. F., Nwosu, J., & Soucek, M. D. (2022). Sustainable thermosets and composites based on the epoxides of norbornylized seed oils and biomass fillers. ACS Sustainable Chemistry & Engineering, 10(37), 12342–12354. https://doi.org/10.1021/acssuschemeng.2c03434

    • Thomas, J., Nwosu, J., & Soucek, M. D. (2023c). Sustainable biobased composites from norbornylized linseed oil and biomass sorghum fillers. Composites Communications, 42, 101695. https://doi.org/10.1016/j.coco.2023.101695

    • Thomas, J., Nwosu, J., & Soucek, M. D. (2023b). Acid-cured norbornylized seed oil epoxides for sustainable, recyclable, and reprocessable thermosets and composite application. ACS Applied Polymer Materials, 5(3), 2230–2242. https://doi.org/10.1021/acsapm.2c02225

    • Tran, V. G., Mishra, S., Bhagwat, S. S., Shafaei, S., Shen, Y., Allen, J. L., Crosly, B. A., Tan, S.-I., Fatma, Z., Rabinowitz, J. D., Guest, J. S., Singh, V., & Zhao, H. (2023). An end-to-end pipeline for succinic acid production at an industrially relevant scale using Issatchenkia orientalis. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-41616-9

    • Wang, Zhe, et al. “Polyelemental nanoparticle synthesis enabled by noncontact metallothermic reactions.” Journal of the American Chemical Society, vol. 147, no. 40, 26 Sept. 2025, pp. 36669–36676, https://doi.org/10.1021/jacs.5c12003

    • Zaini, P. A., Haddad, K. R., Feinberg, N. G., Ophir, Y., Nandi, S., McDonald, K. A., & Dandekar, A. M. (2024). Leveraging walnut somatic embryos as a biomanufacturing platform for recombinant proteins and metabolites. BioTech, 13(4), 50. https://doi.org/10.3390/biotech13040050

    • Zhang, L., Li, Y., Li, R., Yang, X., Zheng, Z., Fu, J., Yu, H., & Chen, X. (2023). Glycoprotein in vitro n-glycan processing using enzymes expressed in E. coli. Molecules, 28(6), 2753. https://doi.org/10.3390/molecules28062753

    • Attal-Juncqua, A., Dods, G., Crain, N., Diggans, J., Dodds, D., Evans, S., Fackler, N., Flyangolts, K., Gibson, K., Kosal, M. E., Kunjapur, A., Read, R., Renda, B., Scown, C. D., Tchedre, K., Ternus, K., Vitalis, B., & Gronvall, G. (2024). Shaping the future US bioeconomy through safety, security, sustainability, and social responsibility. Trends in Biotechnology, 42(6), 671–673. https://doi.org/10.1016/j.tibtech.2023.11.015

    • Rose, P. P., & Friedman, D. (2021). Bioinspired, BioDriven, BioMADE: The U.S. bioindustrial manufacturing and design ecosystem as a driver of the 4th industrial revolution. Engineering Biology, 5(3), 60–63. https://doi.org/10.1049/enb2.12014